About CHILI
The CHILI consortium envisions to optimize cervical cancer screening in low- and middle-income countries by offering a modified, cost-effective version of the point-of-care ELEVATE tool to test self-sampled samples. This promising device, which has the potential to reduce drastically the cancer burden in developing countries, will be implemented in four countries, namely Cambodia, Ethiopia, Mozambique and Uganda.
The ELEVATE tool is a portable cervical cancer screening device being developed during the H2020 project ELEVATE and combines an HPV DNA test with proteomic detection of biomarkers on self-samples from women. The simultaneous and nearly real-time detection of HPV DNA and the proteomic markers allows for the detection of cervical HPV infections progressing towards cervical cancer. Therefore, the test detects patients who need to be referred for close follow-up and/or treatment, and thereby has the potential to reduce drastically the cancer burden in low- and middle-income countries.
The promising ELEVATE tool will be implemented in three low-income countries, namely Ethiopia, Mozambique and Uganda and one lower middle-income country, Cambodia. The acceptability and uptake of the ELEVATE test among women will be compared with that of different, more conventional screening strategies. In addition, the cost-effectiveness will be estimated by economic modelling.
Our motivation for this project
Five key challenges will shape the proposed CHILI project:
- In low- and middle-income countries, basic information on prevalence, incidence and mortality of cervical cancer is lacking, as well as on screening services and coverage.
- Current cervical cancer screening programs are not available, acceptable, and/or cost-effective in low- and middle-income countries, resulting in under-screening.
- Lack of alternatives for HPV testing applicable to low-income settings or point-of-care testing.
- Dearth of evidence-based information on the potential impact of self-sampling screening interventions in low- and middle-income countries and their cost-effectiveness.
- Lack of cervical cancer screening demand and supply.
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